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  • Title: High dose intravenous IgG followed by splenectomy versus splenectomy alone in idiopathic thrombocytopenic purpura refractory to steroids.
    Author: Lang JM, Amaral D, Audhuy B, Barats JC, Boilletot A, Oberling F.
    Journal: Nouv Rev Fr Hematol (1978); 1987; 29(5):285-7. PubMed ID: 3438162.
    Abstract:
    A total of twenty-six patients with idiopathic thrombocytopenic purpura ITP refractory to corticosteroids were alternately allocated to undergo splenectomy alone (N = 12) or to receive a 5 day course of high dose immunoglobulin G i.v. immediately followed by splenectomy (N = 14). Although there were less initial failures after splenectomy in patients receiving IgG, the proportion of sustained complete remission at 1 and 2 years was identical in both groups. It is concluded that high dose IgG infusions do not improve the results of splenectomy in refractory ITP.
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