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  • Title: Nano-hydroxyapatite coated TiO2 nanotubes on Ti-19Zr-10Nb-1Fe alloy promotes osteogenesis in vitro.
    Author: Wu Y, Li Q, Xu B, Fu H, Li Y.
    Journal: Colloids Surf B Biointerfaces; 2021 Nov; 207():112019. PubMed ID: 34388611.
    Abstract:
    Titanium and titanium alloys have broad applications in orthopedic implants due to their excellent mechanical properties and biocompatibility. The biological activity of the metallic implants can be improved by implementing a nano-hydroxyapatite (nano-HA) coating, while it is still challenging to synthesize uniform and stable nano-HA on the metallic materials. The characterization results confirmed that the nanotube array with a diameter of 87 ± 21 nm and a length of 8.1 ± 1.3 μm is achieved by using double anodic oxidation, and then microsphere-like nano-HA crystals are formed on the TiO2 nanotube arrays. Through X-ray diffraction (XRD) and Fourier Transform Infrared Spectrometer (FT-IR) analysis, it is determined that the chemical composition of the coating is hydroxyapatite. in vitro cell experiments, compared to the TZNF metal surface, the TZNF-NTs/HA is beneficial to the proliferation and adhesion of osteoblasts, and the activity of ALP was 6.93 ± 0.47 DEA unit and the content of OCN was 7.04 ± 0.51 ng/L. In terms of the expression of osteogenic gene information as osterix, osteopontin, and osteonectin, the mRNA levels of TZNF-NTs/HA were 2.6-fold, 1.6-fold, and 4.3-fold higher than that of TZNF samples, respectively, at 14 days. The results suggested that the introduction of nano-HA improves osteoblast differentiation and local factor production, as well as indicates the potential for improved implant osseointegration.
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