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  • Title: [Inhalation treatment with low doses of heparin in bronchial asthma patients].
    Author: Petrov D, Tsevtkov O, Gŭrchev R, Kirilov S, Georgieva L.
    Journal: Vutr Boles; 1987; 26(6):98-103. PubMed ID: 3439158.
    Abstract:
    The efficacy of the inhalation treatment of bronchial asthma with low heparin doses was studied in 107 patients 18 to 65 years of age (mean age 43.9 years), men 46 (46.99%), women 61 (57.09%), duration of the disease from 1 up to 18 years. 29 patients (27.10%) had atopic bronchial asthma, 78 patients (72.90%) had mixed and infectious-allergic bronchial asthma. In all patients the disease was in a state of aggravation with various degree of bronchial obstruction. The results of the study show that heparin applied by inhalation in low doses of 5000 U in the course of 10-12 days is highly effective. Positive effect was found in 101 patients (94.39%) and in 84 of them (78.50%) it was considered as very good. Marked good effect was registered in patients who received corticosteroids simultaneously and their doses could be reduced or their application discontinued. It is suggested that the good results of the heparin inhalation treatment were to some extend due to the environmental conditions of the region of Sandanski, South West Bulgaria, where the study was carried out. The resort zone Sandanski is well known for its bioclimatic conditions which are favourable for the treatment of non-specific respiratory infections.
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