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  • Title: [Prognostic significance of dysplastic urothelial changes for the rate of recurrence in superficial urinary bladder cancer].
    Author: Flamm J.
    Journal: Z Urol Nephrol; 1987 Nov; 80(11):641-6. PubMed ID: 3439374.
    Abstract:
    In 54 patients with a superficial transitional cell carcinoma of the bladder urinary (pTa/pTl) apart from a differentiated TUR a quadrant biopsy was investigated in relation to other tumour parameters and the rate of recidivations. Altogether dysplastic changes were to be found in the margin of the tumour in 14 tumours (30%), a positive quadrant biopsy in 20 tumours (37%). Dysplasias in the margin of the tumour without atypias of the remaining mucous membrane were found only in 4 tumours (7%). Dysplasias increase with increasing degree G from 17% in G I tumours to 50% in G III tumours. The rate of recidivations in a control period of 2 years and a chemorecidivation prophylaxis with adriamycin was 14/20 (70%) in positive quadrant biopsy and 6/34 (18%) in negative quadrant biopsy.
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