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  • Title: Animal model of cardiotoxicity: carbon monoxide induced ECG hypoxia masked in light narcosis.
    Author: Mikisková H, Frantík E.
    Journal: Act Nerv Super (Praha); 1987 Dec; 29(4):274-8. PubMed ID: 3439427.
    Abstract:
    Inhalation exposure of restrained conscious rats to carbon monoxide (1000 ppm, 120 min.) led to a peak carboxyhaemoglobine concentration of 40-45%. At this concentrations spontaneous motor activity was not affected significantly but the physical capacity at endurance run was depressed by 70%. From the 30th min. of exposure a typical two-phasic change in heart rate with initial tachycardia and obvious but unstable hypoxic changes in ECG were observed. Quieting of animals (light anesthesia with phenobarbitone; 100 mg/kg ip) removed almost completely all pathological changes. The level and fluctuations of functional requirements to the circulation seem thus substantial for the development of the cardiotoxic effects.
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