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  • Title: Exchange transfusion for severe autoimmune hemolytic anemia.
    Author: Heidemann SM, Sarnaik SA, Sarnaik AP.
    Journal: Am J Pediatr Hematol Oncol; 1987; 9(4):302-4. PubMed ID: 3439579.
    Abstract:
    A 10-year-old patient with severe autoimmune hemolytic anemia (AIHA) presented with heart failure. Hemoglobin levels remained dangerously low despite multiple blood transfusions and corticosteroid therapy. A two-volume exchange transfusion promptly restored and maintained satisfactory hemoglobin levels. An exchange transfusion should be considered in selected patients with AIHA when severe hemolysis results in life-threatening anemia, and repeated blood transfusions are unsuccessful in maintaining safe hemoglobin levels. Such an approach may be especially applicable in children in whom plasma-pheresis may not be suitable because of technical limitations.
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