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  • Title: Lentogenic NDV V protein inhibits IFN responses and represses cell apoptosis.
    Author: Nan FL, Zhang H, Nan WL, Xie CZ, Ha Z, Chen X, Xu XH, Qian J, Qiu XS, Ge JY, Bu ZG, Zhang Y, Lu HJ, Jin NY.
    Journal: Vet Microbiol; 2021 Oct; 261():109181. PubMed ID: 34399297.
    Abstract:
    The V protein of Newcastle disease virus (NDV) has been shown to inhibit the secretion of interferon (IFN) during infection, which is responsible for the promotion of NDV pathogenicity. However, the ability of the V protein to suppress host innate immunity is not well understood. In this study, we explored the function of V protein and its relationship with virulence by generating V protein-inserted recombinant (r) NDVs. Using rNDVs as a model, we examined the efficiency of infection, IFN responses, and apoptosis of host cells during infection. We found that viral propagation occurred smoothly when V protein from lentogenic NDV is inserted instead of the V protein from the velogenic strain. The infection of lentogenic V protein-inserted rNDV induced less expression of IFNs and downstream antiviral proteins via efficient degradation of p-STAT1 and MDA5. Moreover, velogenic V protein triggered a higher apoptosis rate during infection thereby restricting the replication of NDV. Conversely, lentogenic V protein inhibits IFN responses efficiently and induces less apoptosis compared to the velogenic strain. Our findings provide a novel understanding of the role of V protein in NDV pathogenicity.
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