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  • Title: In vitro effect of neuropeptide Y on melatonin and norepinephrine release in rat pineal gland.
    Author: Vacas MI, Sarmiento MI, Pereyra EN, Etchegoyen GS, Cardinali DP.
    Journal: Cell Mol Neurobiol; 1987 Sep; 7(3):309-15. PubMed ID: 3440284.
    Abstract:
    1. To study neuropeptide Y (NPY) effect on melatonin production, rat pineal explants were incubated for 6 hr with 10-1,000 nM NPY in the presence or absence of 10 microM norepinephrine (NE). Melatonin content in the pineal gland and media was measured by radioimmunoassay (RIA). 2. NPY (10-1,000 nM) increased melatonin production and, at 10 or 100 nM concentrations (but not 1,000 nM), enhanced NE stimulation of melatonin production. 3. NPY (1,000 nM) impaired 3H-labeled transmitter release induced by a K+ depolarizing stimulus in rat pineals incubated with 3H-NE. 4. These results suggest that NPY affects both pre- and postsynaptic pineal mechanisms.
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