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  • Title: Evaluating the mechanisms of action and subcellular localization of ruthenium(II)-based photosensitizers.
    Author: Mo J, Mai Le NP, Priefer R.
    Journal: Eur J Med Chem; 2021 Dec 05; 225():113770. PubMed ID: 34403979.
    Abstract:
    The identification of ruthenium(II) polypyridyl complexes as photosensitizers in photodynamic therapy (PDT) for the treatment of cancer is progressing rapidly. Due to their favorable photophysical and photochemical properties, Ru(II)-based photosensitizers have absorption in the visible spectrum, can be irradiated via one- and two-photon excitation within the PDT window, and yield potent oxygen-dependent and/or oxygen-independent photobiological activities. Herein, we present a current overview of the mechanisms of action and subcellular localization of Ru(II)-based photosensitizers in the treatment of cancer. These photosensitizers are highlighted from a medicinal chemistry and chemical biology perspective. However, although this field is burgeoning, challenges and limitations remain in the photosensitization strategies and clinical translation.
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