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  • Title: Distribution of ceftriaxone in the tissues of the female genital system.
    Author: Fraschini F, Zoncada F, Scaglione F, Radaelli U, Miraglia M, Valmaggi P, Falchi M, Ripamonti L.
    Journal: Int J Clin Pharmacol Res; 1987; 7(6):499-502. PubMed ID: 3440640.
    Abstract:
    Twenty-nine patients, hospitalized in order to undergo gynaecological surgery involving organ removal, were treated with a single intramuscular administration of 1 g ceftriaxone before surgery. The tissue levels of the drug determined in the organs considered: uterus, ovary, fallopian tubes, vagina, proved to be comparable and to guarantee its satisfactory and uniform penetration into the tissues of the female genital system at a slowly decreasing rate. The high levels observed 12 h and 24 h after administration (2.24 +/- 0.74 mcg/g; 3.58 +/- 0.60 mcg/g; 0.70 +/- 0.45 mcg/g; 1.20 +/- 0.57 mcg/g in the ovaries and myometrium respectively) suggest a possible application of ceftriaxone in presurgical prophylaxis also in cases of female genital surgery.
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