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  • Title: Genetic conversion of G.C base-pairs to A.U base-pairs in a transfer RNA.
    Author: McClain WH, Seidman JG.
    Journal: J Mol Biol; 1987 Oct 05; 197(3):605-8. PubMed ID: 3441013.
    Abstract:
    The cloverleaf stem segments of the suppressor gene of bacteriophage T4 tRNA(Gln) contain ten G.C and ten A.U base-pairs. To gain a better appreciation of the G.C base-pair requirement, we isolated multiple mutants of this suppressor gene in which base-pairs of G.C were replaced by A.U. One active suppressor gene contained only A.U base-pairs on the anticodon stem, indicating that G.C base-pairs in this region of tRNA(Gln) are not essential for function. In contrast, replacement was not possible at two base-pairs on the D stem and at one base-pair on the T stem.
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