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  • Title: Species-specific immunodiagnosis of Taenia solium cysticercosis by ELISA and immunoblotting.
    Author: Gottstein B, Zini D, Schantz PM.
    Journal: Trop Med Parasitol; 1987 Dec; 38(4):299-303. PubMed ID: 3441736.
    Abstract:
    A combination of ELISA and immunoblotting was evaluated for immunodiagnosis of human T. solium cysticercosis. The sensitivity of ELISA for diagnosis of European, Latin-American, Asian and South African patients with cysticercosis was 75% for serum and 55% for cerebrospinal fluid specimen. Antigens originating from cysticerci in pigs from Mexico and South Africa were of adequate applicability. A species-specific confirmation of T. solium cysticercosis by immunoblotting (detection of antibody activity to the 26 K and 8 K bands) was achieved in 92% (serum) and 100% (CSF) of samples positive in ELISA. No antibodies from 147 patients with other helminth infections reacted with the 26 K and the 8 K band in immunoblotting, resulting in a specificity of 100%.
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