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  • Title: Demonstrating the feasibility of accurately and reliably correcting potassium results for mildly hemolytic samples using a new experimental design.
    Author: van Rossum HH.
    Journal: Clin Chim Acta; 2021 Nov; 522():83-87. PubMed ID: 34418365.
    Abstract:
    BACKGROUND AND AIMS: For several decades, there has been an ongoing debate about the appropriateness and reliability of correcting potassium concentration results for hemolyzed samples. As part of implementing a new Roche Cobas Pro analyzer system the possibility of correcting potassium results in hemolytic samples using a new, thorough experimental design, was investigated. MATERIALS AND METHODS: The relationship between hemolytic index (HI) and increases in potassium concentration was studied by performing a linear regression on hemolysate dilution series (HI 0-160 mg/dL) from 20 left-over patient samples. The obtained correction procedure was validated using another 20 left-over patient samples. Corrections were accepted according to a correction concordance of 100% within the total allowable error criterion of 4.85%. RESULTS: The obtained reporting procedure was: HI 0-17 quantitative potassium reporting, HI 18-100 correct potassium for HI, and report as text including a disclaimer for in vivo hemolysis; samples were rejected for HI > 100. In the validation cohort, 70/70 samples eligible for correction were within the TEa criterion. The maximum negative and positive errors were -2.8% and 2.9%, respectively. CONCLUSION: Correcting potassium concentration results in a designated HI range is feasible and increases the accuracy the potassium results in samples with mild in vitro hemolysis.
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