These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Adverse reactions in a large cohort of patients with inborn errors of immunity receiving intravenous immunoglobulin.
    Author: Esmaeilzadeh H, Askarisarvestani A, Hosseini N, Samimi S, Shafiei A, Mahdaviani SA, Eslami N, Chavoshzadeh Z, Fallahi M, Khakbazanfard N, Shabestari MS, Aleyasin S, Nabavizadeh SH, Cheraghi T, Kalantari A, Ahmadiafshar A, Safari M, Eslamian MH, Molatefi R, Shirkani A, Heidarzadeh Arani M, Tavakol M, Bemanian MH, Arshi S, Nabavi M, Shokri S, Shahhosseini B, Mortazavi N, Nakhaei P, Nazari F, Fallahpour M, Ahanchian H, Moazzen N, Khoshkhui M, Motlagh AV, Aghamohammadi A, Abolhassani H, Yazdani R, Rezaei N.
    Journal: Clin Immunol; 2021 Sep; 230():108826. PubMed ID: 34418548.
    Abstract:
    BACKGROUND: Intravenous immunoglobulins (IVIg) are the major treatment in inborn errors of immunity (IEI) disorders; However, IVIg infusions show some adverse effects. We aimed to assess the adverse reactions of IVIg infusions. METHODS: Data of IVIg infusions in IEI patients were collected from 2011 to 2021. Totally, 363 IEI patients received IVIg regularly in Iran entered the study. The adverse reactions are classified regarding their severity and chronicity. RESULTS: 22,667 IVIg infusions were performed in the study. 157 patients (43.2%) and 1349 (5.9%) infusions were associated with at least one type of adverse reaction. The highest rates of adverse reactions were seen in severe combined immunodeficiency. Myalgia, chills, headache, fever, and hypotension were the most frequent adverse effects of IVIg. CONCLUSION: The reactions affect almost half of the patients mainly in the first infusions which necessitate the close observation of IEI patients receiving IVIg.
    [Abstract] [Full Text] [Related] [New Search]