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  • Title: [Intestinal scleroderma: clinical aspects, diagnostic possibilities and therapy].
    Author: Luderschmidt C.
    Journal: Z Hautkr; 1987; 62 Suppl 1():74-8. PubMed ID: 3442084.
    Abstract:
    Progressive Systemic Scleroderma (PSS) is a generalized disease of the connective tissue, caused by vascular changes, an increased collagen synthesis as well as inflammatory and immunological phenomena. Manifest intestinal scleroderma is a rare complication. The connection of internal symptomatology with esophagus attack is of practical importance. The bacterial deconjugation of bile acids is of pathogenetic relevance, regarding the release of an intestinal symptomatology. This results in a direct application of Tetracycline or Metronidazole by parenteral administration. The increase of unconjugated serum bile acids, such as cholic acid and chenodeoxycholic acid, gives a diagnostic indication which can be carried out in special laboratories by means of gas-chromatography.
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