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  • Title: Formyl peptide chemoattractants. Synthesis and chemotactic activity.
    Author: Falcomer C, Vertuani G, Boggian M, Scatturin A, Spisani S, Cavalletti T, Traniello S.
    Journal: Farmaco Sci; 1987 Nov; 42(11):815-22. PubMed ID: 3443176.
    Abstract:
    The tetrapeptides CHO-Met-Leu-Phe-CO-NH-(CH2)n-COOMe (n = 1-5) have been synthesized. These peptides containing an omega-amino acid residue in position 4 exhibit a very high chemotactic activity. Like the chemotactic peptide CHO-Met-Leu-Phe-OMe, these tetrapeptides in solution undoubtedly adopt an "active" conformation which allows a strong interaction with the receptor on the human polymorphonuclear leukocyte surface.
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