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  • Title: [Use of nifedipine for treating heart failure in the subacute period of myocardial infarct in patients over 60].
    Author: Iakovlev SV, Lazutin VK, Glezer MG, Chistova VS, Sergeeva EV.
    Journal: Kardiologiia; 1987 Dec; 27(12):23-7. PubMed ID: 3444206.
    Abstract:
    The efficiency of nifedipine (an average daily dose of 34.7 +/- 0.2 mg) was examined in 19 patients between 60 and 81 years of age, with myocardial infarction aggravated by heart failure. Single and repeated nifedipine doses taken for 2 weeks produced a 7% drop in arterial BP, a 25% drop in peripheral resistance and a 18% rise in the cardiac index, mostly due to a 17% increase in the stroke index. A significant prolongation of left-ventricular ejection time and an improvement of myocardial contractility were due to smaller poststress and easier left-ventricular blood ejection. Nifedipine improved hemodynamic response to isometric handgrip exercise: peripheral resistance was lower, and the stroke and cardiac indices were higher at the peak of exercise after nifedipine administration, as compared to pretreatment values. Nifedipine is an effective agent for the treatment of postinfarction heart failure accompanied with high peripheral resistance.
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