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  • Title: The analysis of terbutaline in biological fluids by gas chromatography electron impace mass spectrometry.
    Author: Clare RA, Davies DS, Baillie TA.
    Journal: Biomed Mass Spectrom; 1979 Jan; 6(1):31-7. PubMed ID: 34445.
    Abstract:
    A highly sensitive and specific assay is described for the bronchodilator drug terbutaline in human plasma and urine, based on single ion monitoring gas chromatography mass spectrometry and employing a homologue of the drug as internal standard. Recovery of terbutaline and internal standard into ethyl acetate is effected at pH 9.8, while back-extraction into dilute acid serves to purify the initial extract. Following preparation of O-TMS, N-TFA derivatives, the drug and its homologue are detected by selected ion monitoring of their common base ion at m/e 355. The limit of detection of terbutaline by this procedure is 0.3 ng ml-1 from a 4 ml sample of plasma.
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