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  • Title: [Dependence of the synthesis of virion structures in the tick-borne encephalitis virus on the cell culture type].
    Author: Liapustin VN, Lashkevich VA, Mustafina AN, Reshetnikov IA, Chunikhin SP.
    Journal: Vopr Virusol; 1987; 32(6):701-9. PubMed ID: 3445588.
    Abstract:
    Variations in synthesis of antigenic structures are observed in tick-borne encephalitis virus replication in cell cultures of different origin. In a number of cell cultures: pig and Syrian hamster embryo kidney cells, as well as in Chinese striped hamster cells and Tasmanian rat kangaroo cells, virion antigens (VA) are synthesized which differ in the direction of movement in the electric field, namely, anode and cathode VA. In other cell cultures: green monkey kidney, barking deer kidney, and human fibroblasts, only cathode VA is synthesized. In chick embryo fibroblast cultures, in addition to the above-mentioned VA, considerable amounts of a VA which does not move in the electric field are synthesized. In all the cultures, a low molecular nonvirion antigen (NA) is actively produced, the virus-containing fluids of human fibroblast cultures and Chinese striped hamster kidney cell cultures contain lower amounts of high molecular NA, while rat kangaroo and green monkey kidney cell cultures have no high-molecular NA of tick-borne encephalitis virus.
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