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  • Title: Cardioselective antimuscarinic action of a dopamine receptor agonist, N,N-dipropyl-2-aminotetralin (TL-68).
    Author: Sahin I, Ilhan M.
    Journal: Arch Int Pharmacodyn Ther; 1987 Dec; 290(2):185-92. PubMed ID: 3446046.
    Abstract:
    The antimuscarinic action of N,N-dipropyl-2-amino-tetralin (TL-68) was evaluated using guinea-pig isolated electrically paced left atria, spontaneously beating atria and ileal longitudinal muscle. TL-68 competitively antagonized the responses to carbachol but was less potent than atropine in these preparations. TL-68 exhibits higher affinity towards cardiac muscarinic receptors than ileal receptors and, therefore, possesses cardioselective antimuscarinic properties. TL-68 did not show any selectivity for muscarinic receptors mediating negative inotropic and chronotropic effects.
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