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  • Title: Biological effects of a proglumide derivative as cholecystokinin antagonist in conscious dogs.
    Author: Hildebrand P, Beglinger C, Köhler E, Setnikar I, Gyr K.
    Journal: Regul Pept; 1987 Aug 17; 18(3-4):213-20. PubMed ID: 3446223.
    Abstract:
    In conscious dogs we studied the effects of a new cholecystokinin (CCK) antagonist (coded CR 1505) on CCK8-stimulated exocrine pancreatic secretion and release of pancreatic polypeptide (PP). Graded doses of CCK8 (25-400 ng kg-1h-1) were infused i.v. Experiments were repeated against a background infusion of CR 1505 at different doses (0.1, 1 and 10 mg kg-1h-1). The lowest dose of CR 1505 had no biological effects. However, at the upper two doses the compound significantly inhibited the CCK8-stimulated PP release. Furthermore, a significant inhibition of exocrine pancreatic protein secretion was observed with 10 mg kg-1h-1 of CR 1505 (P less than 0.05). The results suggest that CR 1505 could be a useful tool in defining the physiological role of CCK in vivo.
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