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  • Title: Non-hyperammonaemia valproate-induced encephalopathy: A case report.
    Author: Chen L, Xu Z, Huang H.
    Journal: J Clin Pharm Ther; 2022 Mar; 47(3):415-419. PubMed ID: 34462930.
    Abstract:
    WHAT IS KNOWN AND OBJECTIVE: Valproate sodium is an effective antiepileptic drug (AED). Serious adverse effects of valproate sodium are uncommon. This case report illustrates the existence of non-hyperammonaemia valproate-induced encephalopathy. CASE DESCRIPTION: A 47-year-old woman with epilepsy who developed valproate-induced encephalopathy without hyperammonaemia after valproate sodium treatment, and the symptoms completely subsided after withdrawal of valproate sodium. WHAT IS NEW AND CONCLUSION: Early diagnosis and identification of the mechanisms of non-hyperammonaemia valproate-induced encephalopathy are important. Immediate discontinuation of valproate sodium results in rapid resolution of symptoms in these patients.
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