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  • Title: [Radioimmunodetection of human lung cancer xenografts by isotope labeling monoclonal antibody ALT-04 in nude mice].
    Author: Yu YB, Ruan ST, Cai LF, Qiu WR, Fan MZ, Chen ZX, Wu RH, Ma BC, Wu H, Zhong JA.
    Journal: Zhonghua Zhong Liu Za Zhi; 1987 May; 9(3):165-8, 9. PubMed ID: 3447855.
    Abstract:
    Three nude mouse models bearing the human lung cancer were established from two fresh surgical specimens and one cell line. Tumor histological structure and cell morphology were similar before and after transplantation. The monoclonal antibody ALT-04 (McAb ALT-04) against human lung cancer was labeled by 125I, 131I and 201Tl. Radioimmunodetection study showed that all the three kinds of xenografts in nude mice were specifically located by McAb ALT-04. Imaging examination confirmed the ability of isotope labeling McAb ALT-04 to detect the presence of transplanted human lung cancer tissues without the aid of background subtraction manipulations. It is suggested that McAb ALT-04 have the possibility of locating in the tumor diagnosis and guiding in the treatment.
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