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  • Title: Identification of dimethylnitrosoamine metabolites in vitro.
    Author: Grilli S, Prodi G.
    Journal: Gan; 1975 Oct; 66(5):473-80. PubMed ID: 3448.
    Abstract:
    The incubation of dimethylnitrosoamine (DMNA) in the presence of rat liver microsomes leads to production of formaldehyde, formic acid, methylamine, and N-methylhydrazine. When pH 5-enzymes are added to the medium there is also the formation of N-methylhydroxylamide and N,N-dimethylhydrazine. The last compound is the only metabolite produced, to a lesser extent, by the pH 5-enzymes. Thus, the denitrosated or non-denitrosated metabolites are produced either by an oxidative dealkylation and by a reduction of DMNA, catalysed by microsomal and cellular soluble enzymes.
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