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  • Title: Photoredox relay-catalyzed gem-difluoroallylation of alkyl iodides.
    Author: Guo Y, Cao Y, Song H, Liu Y, Wang Q.
    Journal: Chem Commun (Camb); 2021 Sep 23; 57(76):9768-9771. PubMed ID: 34486611.
    Abstract:
    Herein, a new example of relay catalysis, using a combination of Mn2(CO)10 and an iridium-based photocatalyst, is reported. In our relay catalytic reaction, the Mn catalyst and iridium-based photocatalyst catalyze the reaction at different stages in the desired sequence under the same reaction conditions, and do not inhibit each other. This convenient method transforms a broad scope of alkyl iodides into the corresponding gem-difluoroalkenes via C(sp3)-C(sp3) bond construction. The protocol has good functional group tolerance and is suitable for the late-stage modification of multifunctional complex molecules.
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