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  • Title: Gas chromatographic--mass spectrometric determination of haloperidol in plasma. Application to pharmacokinetics.
    Author: Häring N, Salama Z, Todesko L, Jaeger H.
    Journal: Arzneimittelforschung; 1987 Dec; 37(12):1402-4. PubMed ID: 3449072.
    Abstract:
    An improved gas chromatographic-mass spectrometric chemical ionization assay for the quantitative determination of haloperidol in body fluids is presented. A fused silica, bonded phase capillary column, combined with negative ion chemical ionization (NICI), ammonia as a selective reagent gas and the monitoring of preselected characteristic ions (SIM), provide the combined sensitivity and selectivity necessary for reliable measurements in the low ng/ml range. The lower limit of detection was 0.1 ng/ml plasma and the calibration curve linear in the measured range of 0.1-5 ng/ml. In combination with the excellent imprecision and inaccuracy data and a recovery exceeding 90%, the method is very well suited for quantitative determinations of plasma samples generated during clinical studies, e.g. evaluating the pharmacokinetics and/or bioavailability/bioequivalence of haloperidol.
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