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  • Title: Synthesis, biological activity and conformational analysis of some acyclic cholinergic ligands.
    Author: De Amici M, De Micheli C, Pratesi P, Toma L, Grana E, Santagostino-Barbone MG.
    Journal: Farmaco Sci; 1987 Dec; 42(12):921-30. PubMed ID: 3449392.
    Abstract:
    A selected number of acyclic analogs of muscarine were synthesized and tested on rat jejunum. A conformational analysis carried out on compounds (I) and (II), with the Allinger's MM2 program, evidenced that their very low muscarinic activity can be related to the low percentage of the "active conformation" present in solution.
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