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  • Title: Sperm miR-34c-5p Transcript Content and Its Association with Sperm Parameters in Unexplained Infertile Men.
    Author: Dorostghoal M, Galehdari H, Hemadi M, Davoodi E.
    Journal: Reprod Sci; 2022 Jan; 29(1):84-90. PubMed ID: 34494232.
    Abstract:
    MicroRNAs (miRNAs) play an essential role in regulatory functions during gametogenesis. There is evidence that dysregulation of miR-34c-5p is implicated in the pathogenesis of male infertility. Whether miR-34c-5p expression could represent the semen quality and be useful in prediction of the fertilizing ability in normozoospermic men was examined in this study. Normozoospermic infertile patients (n = 15) and fertile men (n = 15) were recruited from the Infertility Clinic of Ahvaz, Iran. Sperm contents of miR-34c-5p transcript in were assessed using real-time polymerase chain reaction. No significant differences were seen in semen characteristics between patients and fertile men. Infertile patients showed significant (p = 0.019) lower contents of sperm miR-34c-5p than fertile controls. Men with lower transcript contents of miR-34c-5p exhibit lower sperm motility and normal morphology. Sperm miR-34c-5p transcript with a relatively good diagnostic power discriminated unexplained infertile men (AUC = 0.751, 95% CI: 0.568-0.934; p = 0.019). Our findings show that sperm contents of miR-34c-5p transcript could reflect the quality of spermatozoa in etiology of unexplained male infertility and be helpful in predicting a successful pregnancy.
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