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  • Title: In vitro effect of trifluoperazine on human lymphocytes.
    Author: Suryanarayana A, Rita P, Reddy PP.
    Journal: Jpn J Exp Med; 1987 Oct; 57(5):277-9. PubMed ID: 3450878.
    Abstract:
    Trifluoperazine, a phenothiazine group of tranquilizer was studied for its chromosome damaging effect in human lymphocyte cultures. The cells were treated with 10, 15 and 20 micrograms/culture of trifluoperazine for 24, 48 and 72 hours. A high incidence of chromatid breaks and gaps was observed after 48 and 72 hours treatment. The study revealed that the drug acts mostly on the late S and G2 phase of the cell cycle.
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