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  • Title: The effects of coumarin on the frequency of deletions in a duplication strain of Aspergillus nidulans.
    Author: Majerfeld IH, Roper JA.
    Journal: Mol Gen Genet; 1978 Feb 16; 159(2):203-6. PubMed ID: 345093.
    Abstract:
    Strains of A. nidulans with a chromosome segment in duplicate show instability resulting from deletions in either of the duplicate segments. In Dp (I, II) strains, with the terminal segment of IR attached terminally to IIR, spontaneous deletions occur most frequently, though not exclusively, from the translocated segment. Coumarin, at concentrations which did not affect viability viability or growth rate, enhanced the instability of Dp (I, II) strains by selectively increasing only the deletion class of highest spontaneous frequency. This selective action is interpreted tentatively as due to inhibition of the repair of a particular class of DNA lesion occurring spontaneously in the attachment region of Dp (I, II) strains.
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