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  • Title: Naphthalimide appended isoquinoline fluorescent probe for specific detection of Al3+ ions and its application in living cell imaging.
    Author: Xu H, Zhang S, Gu Y, Lu H.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2022 Jan 15; 265():120364. PubMed ID: 34520897.
    Abstract:
    Herein, a novel Schiff base fluorescent probe NIQ based on naphthalimide and iso-quinoline units has been readily prepared for the selective detection of Al3+ ions. The obviously visible color changes and prominent fluorescence enhancement were observed upon the addition of Al3+ to NIQ, which could be attributed to the complexation of NIQ with Al3+ and thus leading to the inhibition of photo-induced electron transfer (PET) and the chelation-enhanced fluorescence (CHEF) progress. The limit of detection (LOD) was 52 nM that was far below the standard recommended by the WHO. Binding ratio (1:1) of NIQ with Al3+ ions was supported by Job's plot. The binding constant of NIQ for Al3+ were calculated to be 3.27 × 105 M-1 on the basis of benesi-Hildebrand plot. The plausible binding mechanism for NIQ towards Al3+ ions was evidenced by the density functional theory (DFT) and 1H NMR titration experiment. Furthermore, this "turn-on" probe NIQ has been successfully applied as a biomarker for imaging the Al3+ ions in living cells.
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