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  • Title: [Effect of cholesterol on the level of ascorbic acid in the plasma and tissues of rabbits].
    Author: Nagórna-Stasiak B, Wawrzeńska M, Kopeć R, Lietz W.
    Journal: Pol Arch Weter; 1987; 25(2-3):247-51. PubMed ID: 3452797.
    Abstract:
    Studies were carried out on 10 rabbits divided into two groups. Group I was fed on a physiological diet, group II was given additionally 200 mg of cholesterol daily. After 2 weeks the rabbits were decapitated and, having prepared the tissues according to Zannoni, the level of vitamin C was determined in the plasma, liver and intestinal wall by the method of Roe-Kuenther. It was shown that the diet rich in cholesterol caused a decrease in the level of vitamin C in the organism. The level of ascorbic acid decreased by 57% in the liver and plasms, by 52% in the wall of the caecum, whereas by 30% in the wall of the jejunum. A high level of cholesterol in the organism seems to increase its demand for vitamin C.
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