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Title: [Adherence to adjuvant with therapy imatinib in patients with gastrointestinal stromal tumor: a national multi-center cross-sectional study].
Author: Zhang P, Zhang J, Zhang B, Yang WC, Hu JB, Sun XF, Zhai G, Qian HR, Li Y, Xu H, Feng F, Wu XY, Liu HL, Liu HJ, Qiu HB, Wu XJ, Zhou YB, Shen KT, Kou YW, Fu Y, Jie ZG, Zou XM, Cao H, Gao ZD, Tao KX.
Journal: Zhonghua Wei Chang Wai Ke Za Zhi; 2021 Sep 25; 24(9):775-782. PubMed ID: 34530558.
Abstract:
Objective: To analyze the current adherence to imatinib in patients with gastrointestinal stromal tumors (GIST) in China and its influencing factors. Methods: A cross-sectional survey was conducted. Study period: from October 1, 2020 to November 31, 2020. Study subjects: GIST patients taking imatinib who were diagnosed and treated in public tertiary level A general hospitals or oncology hospitals; those who had not been pathologically diagnosed, those who never received imatinib, or those who had taken imatinib in the past but stopped afterwards were excluded. The Questionnaire Star online surgery platform was used to design a questionnaire about the adherence to adjuvant imatinib therapy of Chinese GIST patients. The link of questionnaire was sent through WeChat. The questionnaire contained basic information of patients, medication status and Morisky Medication Adherence Scale. Results: A total of 2162 questionnaires from 31 provinces, autonomous regions, and municipalities were collected, of which 2005 were valid questionnaires, with an effective rate of 92.7%. The survey subjects included 1104 males and 901 females, with a median age of 56 (22-91) years old. Working status: 609 cases (30.4%) in the work unit, 729 cases (36.4%) of retirement, 667 cases of flexible employment or unemployment (33.3%). Education level: 477 cases (23.8%) with bachelor degree or above, 658 cases (32.8%) of high school, 782 cases (39.0%) of elementary or junior high school, 88 cases (4.4%) without education. Marital status: 1789 cases (89.2%) were married, 179 cases (8.9%) divorced or widowed, 37 cases (1.8%) unmarried. Two hundred and ninety-four patients (14.7%) had metastasis when they were first diagnosed, including 203 liver metastases, 52 peritoneal metastases, and 39 other metastases. One thousand eight hundred and sixty-nine patients underwent surgical treatment, of whom 1642 (81.9%) achieved complete resection. The median time of taking imatinib was 25 (1-200) months. Common adverse reactions of imatinib included 1701 cases (84.8%) of periorbital edema, 1031 cases (51.4%) of leukopenia, 948 cases (47.3%) of fatigue, 781 cases (39.0%) of nausea and vomiting, 709 cases (35.4%) of rash, and 670 cases (33.4%) of lower extremity edema. The score of the Morisky Medication Adherence Scale showed that 392 cases (19.6%) had poor adherence, 1023 cases (51.0%) had moderate adherence, and 590 cases (29.4%) had good adherence. Univariate analysis showed that gender, age, work status, economic income, residence, education level, marriage, the duration of taking medication and adverse reactions were associated with adherence to adjuvant imatinib therapy (all P<0.05). Multivariate analysis showed that female (OR=1.264, P=0.009), non-retirement (OR=1.454, P=0.001), monthly income ≤4000 yuan (OR=1.280, P=0.036), township residents (OR=1.332, P=0.005), unmarried or divorced or widowed (OR=1.362, P=0.026), the duration of imatinib medication >36 months (OR=1.478, P<0.001) and adverse reactions (OR=1.719, P=0.048) were independent risk factors for poor adherence to adjuvant imatinib. Among patients undergoing complete resection, 324 (19.7%) had poor adherence, 836 (50.9%) had moderate adherence, and 482 (29.4%) had good adherence. Meanwhile, 55 patients with good adherence (11.4%) developed recurrence after surgery, 121 patients with moderate adherence (14.5%) developed recurrence, 61 patients with poor adherence (18.8%) developed recurrence, and the difference was statistically significant (P=0.017). Conclusions: The adherence to adjuvant therapy with imatinib in Chinese GIST patients is relatively poor. Females, non-retirement, monthly income ≤4000 yuan, township residents, unmarried or divorced or widowed, the duration of imatinib medication >36 months, and adverse reactions are independently associated with poor adherence of GIST patients. Those with poor adherence have a higher risk of recurrence after surgery. Positive interventions based on the above risk factors are advocated to improve the prognosis of patients with GIST. 目的： 分析国内胃肠间质瘤（GIST）患者伊马替尼服药依从性现状及其影响因素。 方法： 采用横断面调查方法进行问卷调查。调查时间为2020年10月1日至11月31日；调查对象为在具有GIST诊疗资质的公立三级甲等综合医院和肿瘤专科医院诊治，且正在服用伊马替尼的GIST患者，排除未得到病理确诊者和未曾服用伊马替尼者，或既往服用伊马替尼但当前已停药者。使用"问卷星"网络平台设计中国GIST患者伊马替尼服药依从性调查问卷，通过微信方式向调查对象发送问卷链接，问卷内容包括患者基本信息、用药情况及Morisky服药依从性量表。 结果： 共回收2 162份来自全国31个省、自治区、直辖市的GIST患者调查问卷，其中有效问卷2 005份，有效率92.7%。调查对象中男性1 104例，女性901例，中位年龄56（22~91）岁。生活状态：单位在职工作609例（30.4%），退休729例（36.4%），灵活就业及无业667例（33.3%）；文化程度：大学本科及以上477例（23.8%），高中658例（32.8%），小学或初中782例（39.0%），未受过教育88例（4.4%）；婚姻状况：1 789例（89.2%）已婚、179例（8.9%）离异或丧偶，37例（1.8%）未婚。初诊GIST时肿瘤发生转移者294例（14.7%），其中肝脏转移203例，腹膜转移52例，其他部位39例。1 869例（93.2%）接受了手术治疗，其中1 642例（81.9%）行完整切除术。患者服用伊马替尼中位时间为25（1~200）个月，服用伊马替尼的主要不良反应包括眶周水肿1 701例（84.8%），白细胞减少1 031例（51.4%），乏力948例（47.3%），恶心呕吐781例（39.0%），皮疹709例（35.4%）和双下肢水肿670例（33.4%）。Morisky服药依从性量表评分显示，伊马替尼服药依从性差392例（19.6%），依从性中等1 023例（51.0%），依从性好590例（29.4%）。单因素分析显示，患者性别、年龄、居住城市、工作状态、经济收入、居住地、文化程度、婚姻、服药时间及药物不良反应均与患者伊马替尼服药依从性有关（均P<0.05）；多因素分析结果显示，女性（OR=1.264, P=0.009）、非退休（OR=1.454, P=0.001）、月收入≤4 000元（OR=1.280, P=0.036）、居住乡镇（OR=1.332, P=0.005）、未婚或离异或丧偶（OR=1.362, P=0.026）、伊马替尼服药时间>36个月（OR=1.478, P<0.001）及药物不良反应（OR=1.719, P=0.048）是患者伊马替尼服药依从性差的独立影响因素。行完整切除术患者中，依从性差324例（19.7%），依从性中等836例（50.9%），依从性好482例（29.4%），其中依从性好患者术后55例（11.4%）复发，依从性中等患者术后121例（14.5%）复发，依从性差患者术后61例（18.8%）复发，差异有统计学意义（P=0.017）。 结论： 国内GIST患者伊马替尼服药依从性欠佳，女性、非退休、月收入≤4 000元、居住地乡镇、未婚离异或丧偶、伊马替尼服药时间>36个月及药物不良反应是GIST患者服药依从性差的主要影响因素；术后依从性差者复发风险较高；应针对影响伊马替尼服药依从性的因素进行干预和管理，进而改善GIST患者预后。.

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