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  • Title: D-glucose uptake in intestinal brush-border membrane vesicles of rachitic rats.
    Author: Treves C, Favilli F, Iantomasi T, Stio M, Vanni P, Vincenzini MT.
    Journal: Biochem Int; 1987 Jun; 14(6):1121-32. PubMed ID: 3453097.
    Abstract:
    We have previously reported the metabolic consequences of feeding rats Steenbock and Black's rickets-inducing diet, deficient in vitamin D and with an altered Ca/P ratio. Using isolated brush-border membrane vesicles prepared from the jejunum, ileum and duodenum of control and rachitic rats, we have demonstrated a marked decrease of Na+-dependent D-glucose uptake at jejunum-ileum level of rachitic rats. At duodenum level Na+-dependent D-glucose transport was not influenced by rickets. A lack of any significant difference between the two animal groups was observed studying the facilitated transport of D-glucose, the diffusion of L-glucose and the Na+-dependent uptake of phenylalanine and aspartate.
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