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  • Title: Dermatan sulfate isomers in human articular cartilage characterized by high-performance liquid chromatography.
    Author: Murata K, Yokoyama Y.
    Journal: Biochem Int; 1987 Jul; 15(1):87-94. PubMed ID: 3453690.
    Abstract:
    The Constituents of dermatan sulfate isomers in human articular cartilage were studied at the disaccharide level by high-performance liquid chromatography. Appreciable amounts of dermatan sulfate components, i.e., dermatan sulfate, chondroitin sulfate types G and B, could be detected after digestion with chondroitinases-B or -ABC. The oversulfated dermatan sulfate isomers were isolated only after digestion with chondroitinase-ABC but not with the AC-lyase. The dermatan sulfate isomers were found to be markedly increased in weight loading parts of articular cartilage. It is postulated that the dermatan sulfate isomers are formed as a result of the weight loading reaction, which may be responsible for the fibrosis of articular cartilage.
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