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  • Title: Monitoring of chronic wasting disease using real-time quaking-induced conversion assay in Japan.
    Author: Suzuki A, Sawada K, Erdenebat T, Yamasaki T, Tobiume M, Suga K, Horiuchi M.
    Journal: J Vet Med Sci; 2021 Nov 16; 83(11):1735-1739. PubMed ID: 34556606.
    Abstract:
    There has been no report on Chronic wasting disease (CWD) cases in Japan to date; however, there is concern about the geographic spread of CWD. To clarify the CWD status in Japan, we conducted CWD monitoring using real-time quaking-induced conversion (RT-QuIC) assay which can detect the low level of CWD prions. A total of 690 obex samples collected from sika deer and Reeves's muntjac in Hokkaido and Honshu was tested for CWD prions. No CWD-positive cases were found, suggesting that CWD is nonexistent in Japan. Our results also indicate that RT-QuIC assay is useful for continuous monitoring of CWD. Furthermore, nucleotide sequence analysis of the PrP gene revealed sika deer in Japan harbor CWD susceptible allele.
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