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  • Title: Chromosomal localization of the human apolipoprotein B gene and detection of homologous RNA in monkey intestine.
    Author: Deeb SS, Disteche C, Motulsky AG, Lebo RV, Kan YW.
    Journal: Proc Natl Acad Sci U S A; 1986 Jan; 83(2):419-22. PubMed ID: 3455779.
    Abstract:
    A cDNA clone of the human apolipoprotein B-100 was used as a hybridization probe to detect homologous sequences in both flow-sorted and in situ metaphase chromosomes. The results indicate that the gene encoding this protein is on the distal end of the short arm of chromosome 2 (2p23-2p24). RNA isolated from monkey small intestine contained sequences (6.5 and 18 kilobases) homologous to the cDNA of apolipoprotein B-100. These results are consistent with the hypothesis that one gene codes for both the intestinal (B-48) and the hepatic (B-100) forms.
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