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  • Title: The Role of Intracellular Signaling Molecules in the Production of Granulocytic CSF Mononuclear Phagocytes in Stress and Cytostatic Influence.
    Author: Zhdanov VV, Miroshnichenko LA, Zyuz'kov GN, Khrichkova TY, Udut EV, Simanina EV, Sherstoboev EY, Stavrova LA, Agafonov VI, Danilets MG, Trofimova ES, Minakova MY, Dygai AM.
    Journal: Bull Exp Biol Med; 2021 Aug; 171(4):411-415. PubMed ID: 34561791.
    Abstract:
    Under conditions of steady-state hemopoiesis, nuclear factor NF-κB, in contrast to MAP kinase p38, plays an important role in the maintenance of the initial level of secretory activity of monocytes. The increase in the production of G-CSF under stress conditions (10-h immobilization) is mainly regulated by the alternative p38MARK signaling pathway via activation of p38 synthesis. It was shown that under conditions of cytostatic-induced myelosuppression, the production of protein kinase p38 in cells decreases, and it, like NF-κB, is not the main one in the production of hemopoietin by mononuclear phagocytes.
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