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  • Title: Determination of 7-hydroxymethotrexate in human plasma by reversed phase high-performance liquid chromatography.
    Author: Erttmann R, Bielack S, Landbeck G.
    Journal: Oncology; 1986; 43(2):86-8. PubMed ID: 3456549.
    Abstract:
    A rapid and sensitive reversed phase HPLC method was developed for the detection of 7-hydroxymethotrexate (7-OHMTX) which is the main metabolite in human plasma after high-dose methotrexate (MTX) therapy. The simple clean-up procedure of plasma samples described allows the measurement of 7-OHMTX during clinical management of MTX infusions. Elimination kinetics of 7-OHMTX are given from 53 drug cycles of 6 patients.
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