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  • Title: Prostaglandin synthesis by rat uterine homogenates in the presence of copper ions, and the effects of indomethacin and salicylic acid.
    Author: Peplow PV, Hurst PR.
    Journal: Prostaglandins Leukot Med; 1986 Jan; 21(1):15-22. PubMed ID: 3456618.
    Abstract:
    While no significant effects on the in vitro production of PGF2 alpha by homogenates of rat estrous uteri were observed in the presence of 10(-3) and 10(-6) M Cu2+, the presence of Cu2+ at 10(-4) and 10(-5) M was found to stimulate production with maximal synthesis of PGF2 alpha occurring with 10(-4) M Cu2+. By contrast, the synthesis of PGE2 and PGI2 (determined as 6-keto PGF1 alpha) were unaffected at all of the different Cu2+ concentration used. When indomethacin and salicylic acid were tested for their effects on the Cu2+-mediated levels of PG synthesis by the homogenates, indomethacin (at 20 microM) was found to cause similar pronounced decreases in PGF2 alpha, PGE2 and 6-keto PGF1 alpha whereas salicylic acid (400 microM) showed preference towards suppressing PGE2 and 6-keto PGF1 alpha production.
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