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  • Title: Screening of a glycopolymer library for GM1 mimetics synthesized by the "carbohydrate module method".
    Author: Nagao M, Uemura T, Horiuchi T, Hoshino Y, Miura Y.
    Journal: Chem Commun (Camb); 2021 Oct 19; 57(83):10871-10874. PubMed ID: 34585193.
    Abstract:
    The "carbohydrate module method" is a promising approach for oligosaccharide mimetics using polymeric materials. However, it is difficult to predict the optimal structure for a particular oligosaccharide mimetic, and an efficient strategy for the synthesis and evaluation of glycopolymers is desirable. In this study, a screening of glycopolymers for the "carbohydrate module method" by a combination of photoinduced electron/energy transfer-reversible addition-fragmentation chain-transfer (PET-RAFT) polymerization and surface plasmon resonance imaging (SPRI) is demonstrated. The facile and fast screening of synthetic glycomimetics was achieved, and the glycopolymer with the optimal structure as a GM1 mimetic strongly interacted with the cholera toxin B subunit.
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