These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Risk factors of early septic shock-related thrombocytopenia and its impact on prognosis].
    Author: Xu X, Wang H, Wu X, Yu J, Zheng R.
    Journal: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue; 2021 Aug; 33(8):938-943. PubMed ID: 34590560.
    Abstract:
    OBJECTIVE: To investigate the risk factors and prognosis of early septic shock-related thrombocytopenia. METHODS: Retrospective analysis of clinical data of patients with septic shock admitted to the department of intensive care unit (ICU) of Northern Jiangsu People's Hospital from June 2016 to November 2020 was conducted. According to the lowest platelet count (PLT) in the early stage of septic shock (within 24 hours of using vasoactive drugs), the patients were divided into mild thrombocytopenia group [PLT (50-100)×109/L], severe thrombocytopenia group (PLT < 50×109/L) and normal platelet group (PLT > 100×109/L). The differences in general information, laboratory indicators, mechanical ventilation time, length of ICU stay, in-hospital stay, and 28-day mortality among the three groups were analyzed. Multivariate Logistic regression was used to analyze the influencing factors of thrombocytopenia, and the 28-day Kaplan-Meier survival curve of patients with different PLT levels was drawn. RESULTS: A total of 486 patients with septic shock were enrolled, including 123 patients with mild thrombocytopenia, 75 patients with severe thrombocytopenia and 288 patients with normal platelets. Patients with diabetes (χ2 = 30.460, P < 0.001), abdominal infection (χ2 = 15.024, P = 0.001), urinary tract infection (χ2 = 36.633, P < 0.001), bloodstream infection (χ2 = 7.755, P = 0.022), Gram negative (G-) bacilli infection (χ2 = 19.569, P < 0.001), hyperlactic acidemia (H = 23.404, P < 0.001), elevated procalcitonin (PCT, H = 43.368, P < 0.001), high acute physiology and chronic health evaluation II (APACHE II, F = 11.122, P < 0.001) and high sequential organ failure assessment (SOFA, F = 84.328, P < 0.001) were more likely to have thrombocytopenia within 24 hours of septic shock. Multivariate Logistic regression analysis of early septic shock-related thrombocytopenia showed that, diabetes [odds ratio (OR) = 0.19, 95% confidence interval (95%CI) was 0.08-0.42, P < 0.001], urinary tract infection (OR = 0.33, 95%CI was 0.13-0.83, P = 0.018), G- bacilli infection (OR = 0.20, 95%CI was 0.07-0.58, P = 0.003), hyperlactic acidemia (OR = 1.25, 95%CI was 1.07-1.46, P = 0.005) and high APACHE II score (OR = 0.85, 95%CI was 0.78-0.92, P < 0.001) were independent risk factors for platelets < 50×109/L. Abdominal infection was an independent risk factor for PLT (50-100)×109/L (OR = 0.56, 95%CI was 0.34-0.95, P = 0.03). High SOFA score was an independent risk factor for PLT ≤ 100×109/L [PLT < 50×109/L: OR = 2.03, 95%CI was 1.65-2.52, P < 0.001; PLT (50-100)×109/L: OR = 1.31, 95%CI was 1.16-1.48, P < 0.001]. There were no significant differences in mechanical ventilation time, length of ICU stay, and in-hospital stay among the three groups (H values were 0.142, 2.134, and 3.990, respectively, all P > 0.05). The 28-day mortality of septic shock patients increased with the severity of thrombocytopenia (χ2 = 40.406, P < 0.001), and the 28-day mortality of severe thrombocytopenia group and mild thrombocytopenia group was significantly higher than those of the normal platelet group [66.7% (50/75), 43.1% (53/123) vs. 27.8% (80/288), both P < 0.05]. Kaplan-Meier survival curve analysis showed that the 28-day survival rate gradually decreased with the decrease of PLT, and the 28-day survival rate was higher in the normal platelet group (Log-Rank test: χ2 = 80.667, P < 0.001). CONCLUSIONS: Diabetes, abdominal infection, urinary tract infection, G- bacilli infection, hyperlactic acidemia, high APACHE II score, and high SOFA score are independent risk factors for early septic shock-related thrombocytopenia. Early thrombocytopenia in patients with septic shock indicates a high risk of 28-day death.
    [Abstract] [Full Text] [Related] [New Search]