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  • Title: Immunohistochemical demonstration of choline acetyltransferase-immunoreactive preganglionic nerve fibers in guinea pig autonomic ganglia.
    Author: Lindh B, Staines W, Hökfelt T, Terenius L, Salvaterra PM.
    Journal: Proc Natl Acad Sci U S A; 1986 Jul; 83(14):5316-20. PubMed ID: 3460095.
    Abstract:
    The distribution of choline acetyltransferase (ChoAcTase)-like immunoreactivity in the superior cervical ganglion and the stellate ganglion was analyzed with immunohistochemistry. A dense network of ChoAcTase-immunoreactive nerve fibers was observed in both ganglia studied. The ChoAcTase-positive fibers were found in all parts of the ganglia but had a differential distribution, giving rise to a patchy staining pattern. After preganglionic denervation of the superior cervical ganglia, all ChoAcTase-positive fibers disappeared. For comparison, the distributions of enkephalin- and neuropeptide Y-like immunoreactivity were analyzed. In the stellate ganglion, the enkephalin-positive fibers had a marked regional distribution. Areas with the highest enkephalin-fiber density seemed to contain low numbers of ChoAcTase-positive fibers and vice versa. The findings give evidence for occurrence of acetylcholine synthesis in preganglionic fibers in paravertebral sympathetic ganglia.
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