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  • Title: Acute lymphoblastic leukemia at relapse in a child with acute myeloblastic leukemia.
    Author: Bernstein ML, Esseltine DW, Emond J, Vekemans M.
    Journal: Am J Pediatr Hematol Oncol; 1986; 8(2):153-7. PubMed ID: 3461717.
    Abstract:
    We describe a child diagnosed as having acute myelogenous leukemia (AML) at 25 months of age who relapsed with acute lymphoblastic leukemia (ALL) 1 year later. The AML was morphologically M2 by the French-American-British classification, periodic acid Schiff (PAS) stain negative and peroxidase positive. The ALL was L1 by this classification, PAS positive, and peroxidase negative. The initial AML was associated with a small segment deletion of the long arm of chromosome 11 [46, XY, de (11) (q23)] not seen in the relapse ALL, which had a normal karyotype. The child was rapidly reinduced with vincristine and prednisone, and remains in remission on maintenance lymphoma type (LSA2-L2) therapy more than 2 years later. These findings suggest the development of a new leukemic clone, rather than a phenotypic modulation of the initial leukemia.
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