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  • Title: Coronavirus disease 2019 and peripheral blood eosinophil counts: a retrospective study.
    Author: Eijmael M, Janssens N, le Cessie S, van Dooren Y, Koster T, Karim F.
    Journal: Infection; 2021 Dec; 49(6):1325-1329. PubMed ID: 34625911.
    Abstract:
    PURPOSE: Eosinopenia has been described in COVID-19. With this study, we aim to study the peripheral blood eosinophil counts in COVID-19 patients and to investigate whether there is an association between the peripheral blood eosinophil counts and disease severity of COVID-19. METHODS: We revised the electronical medical records of confirmed COVID-19 patients with polymerase chain reaction (PCR) assays in the Groene Hart Ziekenhuis, Gouda, The Netherlands. We divided patients in mild, moderate and severe groups based on clinical severity of COVID-19. Clinical severity was based on the therapy needed and the outcome of patients. We compared clinical characteristics, laboratory results and outcome between the three groups. RESULTS: Of the 230 patients included in this study, the mild, moderate and severe groups consisted of 16.5%, 45.7% and 37.8% of the included patients, respectively. The mean age was 68 years (IQR 57-78). 63% of patients were male. A significant decrease in the peripheral eosinophil counts was found corresponding to the increase of COVID-19 severity. In the mild, moderate and severe groups, the percentage of patients with eosinopenia was 73.7%, 86.7% and 94.3%, respectively (p value 0.002). CONCLUSION: Eosinopenia is significantly more frequent present in patients with a severe COVID-19.
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