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  • Title: [Karyotypic characteristics of the murine myeloma line sp2/0-Ag14].
    Author: Sorokina EA, Kozhukharova IV, Grinchuk TM.
    Journal: Tsitologiia; 1986 Jun; 28(6):623-8. PubMed ID: 3463006.
    Abstract:
    Using methods of G- and C-banding, a study was made of the karyotype of mouse myeloma cell line sp2/0-Ag14. The number of chromosomes varies from 58 to 65, the modal class being 61-62. 50 per cent of chromosomes are rearranged. Normal chromosomes 6, 12 and X were not detected in either examined cell of this line. Among the marker chromosomes there are an isochromosome (19/19), three dicentric markers and one marker with two interstitial C-bands. There is a specific marker t (12; 15) of mouse plasmacytomas in the karyotype sp2/0-Ag14. A possible association of specific translocations and segregations of the normal chromosomes with the phenotype of line sp2/0-Ag14 is discussed. The results obtained may be useful for cytogenetic analysis of hybridomas.
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