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  • Title: Acute myelomonocytic leukemia (M4) with eosinophilia: problems concerning chromosome 16 abnormality.
    Author: Harth H, Pees H, Zankl H.
    Journal: Cancer Genet Cytogenet; 1986 Oct; 23(2):127-33. PubMed ID: 3463402.
    Abstract:
    A case of acute myelomonocytic leukemia is reported which was hematologically classified as M4 (FAB), because the patient had a high count of immature eosinophils with typical histochemical features in the bone marrow. An abnormal chromosome #16 was found besides a trisomy 22 or a monosomy 18 in part of the cultured bone marrow cells and unstimulated blood cells but not in directly prepared bone marrow. The structural aberration of chromosomes #16, which was demonstrated best by CBG-banding, was more likely due to a partial deletion of the long arm than to an inversion. The difficulties involved in correct cytogenetic diagnosis of such cases are discussed.
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