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  • Title: Intramolecular charge transfer enhancing strategy based MAO-A specific two-photon fluorescent probes for glioma cell/tissue imaging.
    Author: Fang H, Shi R, Chen D, Qu Y, Wu Q, Yang X, Lu X, Zhang CW, Li L, Lim KL.
    Journal: Chem Commun (Camb); 2021 Oct 26; 57(85):11260-11263. PubMed ID: 34636370.
    Abstract:
    MAO-A promotes the proliferation of human glioma cells. Herein, we report a series of MAO-A specific two-photon small molecular fluorescent probes (A1-5) based on an intramolecular charge transfer enhancing strategy. The activity of endogenous MAO-A can be selectively imaged using A3 as a representative probe in different biological samples including human glioma cells/tissues via two-photon fluorescence microscopy. The study provides new tools for the visual detection of glioma.
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