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  • Title: Mobilization of intracellular calcium as a mechanism for the positive inotropic effect by prostaglandin F2 alpha in isolated guinea pig atria.
    Author: Otani H, Sugimoto J, Morita M.
    Journal: Prostaglandins Leukot Med; 1986 Sep; 24(1):51-6. PubMed ID: 3464026.
    Abstract:
    The mechanism of the positive inotropic effect of prostaglandin F2 alpha (PGF2 alpha) was investigated using spontaneously beating isolated guinea pig atria. PGF2 alpha increased the contractile force in a concentration dependent fashion in a range between 10(-7)M to 10(-5)M. The maximal response to PGF2 alpha was obtained within 5 min and continued for at least 20 min. This positive inotropic effect of PGF2 alpha was not affected by verapamil, but was inhibited by procaine or TMB-8, potent inhibitors of Ca2+ release from intracellular Ca2+ compartments. Increase in extracellular Ca2+ concentration failed to provoke a significant positive inotropic effect by PGF2 alpha, suggesting that this response is relatively independent of extracellular Ca2+. These results suggest that the PGF2 alpha-mediated positive inotropic effect is produced by a mobilization of intracellular Ca2+.
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