These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Supernatants from ethanol-containing macrophage cultures have cytotoxic activity.
    Author: Wickramasinghe SN.
    Journal: Alcohol Alcohol; 1986; 21(3):263-8. PubMed ID: 3464283.
    Abstract:
    After macrophages are cultured in the presence of ethanol (0.1-2.0 mg/ml) for 72 hr, the culture supernatant contains one or more cytotoxic factors which cause the detachment of mouse A9 tumour cells and a reduction of 3H-thymidine incorporation by K562 cells. The cytotoxic activity is largely abolished by heating to 56 degrees C for 10 min and is non-dialysable and hence associated with material having a molecular weight greater than about 10,000. These in vitro data support the possibility that alcohol-induced tissue damage may result from the action of cytotoxic factors generated as a consequence of an interaction between ethanol and tissue macrophages in vivo.
    [Abstract] [Full Text] [Related] [New Search]